iNSIGHT:

Intelligent Encapsulation & Screening Platform for Precision Delivery of Probiotics

About iNSIGHT

The challenge:

Over the past decades, lifestyle and diet changes have disrupted our gut microbiota, contributing to a rise in non-communicable diseases and microbiome-related health conditions.

Probiotics are a promising way to support and restore a healthy gut microbiome. However, many next-generation strains are extremely sensitive to oxygen, moisture, heat, and gastric acid. This means that, in real life, only a small fraction of the ingested probiotics survive long enough to reach the intestine and exert their beneficial effects.

Our approach:

iNSIGHT tackles this challenge by developing precision probiotics: probiotic formulations that are protected, targeted, and tunable.

We design and test customisable microcapsules that:

Shield sensitive probiotic strains from harsh environments
Enable targeted post-stomach release
Can be adapted to different strains and patient needs

To do this, we integrate bi-gel-based microencapsulation, microfluidic gut-on-a-chip devices, and machine learning to understand, predict, and control how probiotics are released in the gastrointestinal tract.

About iNSIGHT

At iNSIGHT, we are developing a next-generation probiotic delivery system designed to overcome the challenges of stability, targeted release, and therapeutic efficacy. By combining advanced bi-gel microencapsulation, gut-on-a-chip technology, and AI-driven optimization, we ensure probiotics survive harsh conditions and reach their site of action intact and effective.

Our research advances both probiotic formulations and delivery mechanisms, enabling precision probiotics tailored to individual microbiome needs. By bridging cutting-edge encapsulation science with high-throughput screening and machine learning, we are paving the way for personalized microbiome-based therapies that redefine gut health and disease management.